A simple, rapid, accurate and precise vierordt’s method was developed for the simultaneous estimation of domperidone and ilaprazole in pure and capsule dosage form. Domperidone and ilaprazole exhibited absorbance maximum (λmax) at 286.4nm and 302.4nm in methanol. Based on their λmax, both the drugs were analysed by simultaneous equation method or vierordt’s method using precise formula. The developed method was validated for linearity, range, accuracy, precision, robustness and specificity, limit of detection and limit of quantitation as per ICH guidelines. Linearity of domperidone and ilaprazole were found to be 9 -27 µg/ml and 3-9 µg/ml respectively with significantly high value of correlation coefficient (R2). The limit of detection and limit of quantification for domperidone and ilaprazole were found to be 118.66 ng/ml, 359.59 ng/ml and 66.53 ng/ml, 201.61 ng/ml respectively. The proposed vierordt’s method was found to be efficient, precise, accurate, specific and useful for the regular analysis of domperidone and ilaprazole in pure and pharmaceutical dosage form.
Loading....